Mechanisms and Management of Diabetic Painful Distal Symmetrical Polyneuropathy

Mechanisms and Management of Diabetic Painful Distal Symmetrical Polyneuropathy

Although a number of the diabetic neuropathies may result in painful symptomatology, this review focuses on the most common: chronic sensorimotor distal symmetrical polyneuropathy (DSPN). It is estimated that 15-20% of diabetic patients may have painful DSPN, but not all of these will require therapy. In practice, the diagnosis of DSPN is a clinical one, whereas for longitudinal studies and cli...

Recent advances in the management of diabetic distal symmetrical polyneuropathy

There is now little doubt that poor blood glucose control is an important risk factor for the development of diabetic peripheral neuropathy (DPN). Furthermore, traditional cardiovascular risk factors for macrovascular disease appear to be associated with an increased risk of DPN. The recently established International Expert Group on Diabetic Neuropathy has recommended new criteria for the diag...

Distal symmetrical polyneuropathy in a dog.

A 1.3-year-old Great Dane dog had a chronic progressive neurologic disease clinically expressed as a distal symmetrical polyneuropathy characterized by weakness and bilateral atrophy of bulbar and distal appendicular musculature. Qualitative and quantitative studies showed neurogenic atrophy of muscles below the elbow and stifle. There was Wallerian-type degeneration, Schwann cell proliferation...

Sensory Neuropathies Chronic Sensorimotor Distal Symmetrical Polyneuropathy

Risk factors for HIV-distal symmetrical polyneuropathy: A review

Objective: To review the risk factors of HIV distal symmetrical polyneuropathy. Methods: A MEDLINE search of the English-language literature using a combination of words (HIV, neuropathy, risk factors) was used to identify original studies, consensus statements, and reviews published in the last 20 years. Results: The various risk factors for HIV-distal symmetrical polyneuropathy. Conclusion: S...